I've got an early '70's or so Model 10-5 who's barrel is a degree or two off but at the range it's intended to shoot and I practice with it I've never been able to see any major problems. I noticed this more than twenty years ago and never thought too much about it, other than being a bit odd.
If I had one in a target type revolver I'd be concerned, but the fixed sights and 2" barrel don't cause me much heartache.
RD

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