Are you just out to harm prairie dogs and woodchucks, or do you expect to shoot coyotes and bobcats and feral dogs?

Going to call-in predators? Take deer, too?

I'd lean toward the .243 for bigger animals. But barrel life is probably better with a .223. Not sure, compared to a .22/250, and the Swift is a barrel burner. Don't think I'd want one of those or a .264.