I carry a 340PD and I like heavy bullets. Since I've never shot a 357 load less than 158 grains, there's no risk of flashing the titanium cylinder. I shoot my other guns a lot, but not the 340PD or the 329PD.

If you are thinking of shooting the pistol a lot, then the Scandium/Titanium or Scandium/Stainless pistols are not the longest-lived. I think that's true in general of any super-lightweight pistol. If you shoot a lot of the wrong loads even in a stainless cylinder scandium frame you will have to send it back to S&W periodically to get the stainless blast shield replaced.

The 340PDs are great carry guns, and I think the 2 oz does make a difference.