It is going to depend on how hard the cast bullets are.....if they are hard, then generally you can drive them as you would a comparable weight jacketed bullet.....I cast SWC's plain base bullets out of straight wheel weights and haven driven them with 15 gr. of 2400.....my normal load is 13.5 of 2400 as it does anything I ask of it. I have harvested several deer with this load from a 6" M-28....if it was me, I would throttle back a bit from a max load, see how they shoot and how your bore looks as far as leading goes....then proceed.