Once I've chambered a round it stays there unless I need to clean or secure the piece. If for whatever reason I need to unload it I stand it next to a factory fresh round to check for set back, if it still mikes out, it goes back on top the mag and gets re-chambered.
You should shoot your carry ammo(what's in your mags) once a year and put fresh in, unless its exposed to the elements or sweat. Most ammo is waterproof, but sweat is salt based and it can corrode your brass or what's know as verdigris. And you should train with your carry ammunition too. Dale

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"Long live the S&W 3rd. Gen.!"