I carry a Glock 23 most of the time, and it stays loaded. I haven't cleaned it for 450 rounds. I do add lube; Slip 2000 EWL as needed--this is the only time I unload it. I may clean it when it reaches 500 rounds, we'll see. I chamber a round once from the magazine, and after it comes out it gets relegated to practice.

I bought another Glock 23 to use for dry fire, range practice, and as a back up.