OH, yeah. I've had two Old Model (3-screw) 4 5/8" .45 convertible Blackhawks; sold one and regretted it, now have only one. I also have a large-frame hi-polish stainless .45 Vaquero convertible; retrofitted the action so it loads like the original Blackhawks and Colt single actions. I also have a non-convertible large-frame Vaquero Bisley model in .45 Colt, similarly modified.
Like some of the others mentioned here, the .45 Colt cylinders get the most use, and that's where the guns shine. From cowboy loads to hell-for-leather .44 Mag-equivalent loads, these revolvers have no peers. They are built like tanks, and it would take Godzilla to tear one apart. Amazingly versatile and a whole lot of fun to shoot.
John