I currently jhave 2 "OM" Vaqueros and an OM (three srew) Blackhawk. In the 70's I used one for guiding on wild hogs with "hot" handloads. I now carry one when in grizzly country with "Ruger Loads":. I also use it 45 Colt for cowboy. I also have an antique Colt Bisley (in the mail now), had a Vaquero Bisley and a S & W Model 1989, have an 1878 Colt double action, a '73 Uberti, and a few others Colts SAAs.

Yes. I like the caliber and use it. Personally, it's likely the best choice in a firearm, if you had to choose one only. The ("older") Blackhawks and Vaqueros can handle anything you load, from cowboy black-powder loads to "mini" 454 loads. But, be sure it's a large frame Ruger, before you load the hot stuff.