I own three 25-5's in .45 colt. With a 4" bbl -- shooting .454 lead reloads, I get 9-ring accuracy on a B-27 target at 25 yards. With my two 6" bbls -- both shooting .454 lead reloads -- I get 10-ring accuracy. Actually measured, it's just under 2" groups -- from a rest.
For defense, any of the three is great. For hunting -- well, it would depend on what you're hunting and how far away.
To anyone wondering about the .45 colt with oversized throats: just buy it. Try different loads using a .454 lead bullet and you will find one that works for you
By the way, my 4" likes Silvertips and just chews the center out of the target with them -- as do the 6 inchers, though they like lead.
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