I found in my 460 that the 2400 was a good powder. The 240 gr Hornady was harder to find a good load for. The 200 gr FTX likes the 2400. And so does the 240 gr. I ended up using 4227 for the 300 gr Honady. H110 just didn't seem to do it for me. The leather sand bag took a beating from the cylinder blast and cut through it. I also blew my front sand bag apart with muzzle blast when I got too far back. I am using the 12" version. I would post pics but can't get them to show up using photobucket.