I carried a CZ-83 IWB for about a year. Although not full size, it was still an all steel gun with hi-cap mag and some weight to it, and it never gave me any issues at all. It was comfortable even while seated.

Other then for age or medically related reasons, I just don't understand those who feel they cannot ever carry anything bigger then a J-Frame (and sometimes not even that), and I'm no big tough guy.