If you think the 25 ACP is dead, check ammo sales.

IIRC, the 25 ACP 50 gr fmj was shown as 25% one shop stops. The other bullet types show about the same. I would use one of the flat nosed or HP loads are they are less likely to bounce off a skull.

The 32 ACP and 380 ACP with ball loads show 50% one shot stops. So do 38 Special standard 158 gr LRN from a 2 inch with 55% from a 4 inch.

So, I would say the 25 ACP is a good threat. I would just get one of the tiny 32 ACP pistols if I needed a tiny gun. You can up the stats a little bit with the Silvertip 32 ACP load if it functions in your pistol.

I wouldnt choose the 25 ACP for carry but just the threat of a gun will stop most problems.