You should check out HKs. Especially the USP models. They have fairly large frame/grips, and the trigger guard is nice and large...

Not sure if Glock will work for you. I went to a gun show with my brother in law before, and he was looking for a handgun for home defense. I suggested that he look at a G19, or G17. Well, his hand was so big it just swallowed up the grip and he couldn't even get his finger in the trigger guard!! Looked like a kids' toy gun in his hand. He's not overweight, or anything, just a big guy. He's got what I call 'ham' hands. His hands are so big, they look like a Christmas ham.

__________________
NRA Life Member