I can't comment on the takedown screw coming loose during shooting since my Victory extractor left the range on my first shot. However, I will comment on how hard the takedown screw was torqued from the factory. I could not break it loose with the allen wrench included, nor with a hex bit in my Brownells kit. I finally took the original allen wrench and added a much longer, stronger handle to it to break it loose. In retrospect, that is probably a clue from the factory about loosening during use.

I have no problem using locktite when needed. Most of my S&W revolvers loosen screw(s) during use.

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Bob.
SWCA 1821