Loctite is not intended for use on screws that must repeatedly be removed and reapplied.
S&W copied this feature from the Browning Buckmark. And this is the reason that I sold my Buckmark. In order to clean the gun, you had to remove a screw that held the barrel to the frame. And the screw would often come loose while I was shooting the gun in competitions. If you repeatedly use Loctite on the screw, it won't be long before you have a mess on your hands.
I feel that using a screw to attach the barrel to the frame is a design mistake.