OK, given the OP is long gone the title still got my attention.

The answer is I wouldn't.

Yeah, with the right shot placement it will work but as an SD gun, just no. I do carry a 22 mag as my primary at times and even there it is more a belly gun to give me time to escape as the attacker winces or a show stopper if I can put it to his head or neck.

Sure you can practice more with a 22 but that is just general practice like working on trigger basics or other general shooting stuff.

Just my 2 cents on something I would bet doesn't come up often.