Always check the strain screw and ejector rod tightness, even a new revolver. The first can cause misfires and the second hard opening the cylinder. Always use the right tools.

.22 LR runs extremely dirty. Clean all chambers thoroughly. Scrub under the extractor star and in cylinder recesses. Any dirt here will make opening difficult and may cause misfires.

Revolvers are a lot more reliable than pistols for .22 LR, especially with cheap ammo. CCI seems to work best.