I know all about the eyes... mine seem to be going down hill as well.
In almost all self defense cases you have a split second to make a shot. And are usually in close proximity... and then you have the adrenaline rush also. So it comes down to a point and shoot scenario. My opinion is use what ever gun feels comfortable in your hand and practice with that gun and it's functions. I just seen you are a LEO so I'm not telling you anything you don't already know... lol