Handloads should improve the effect, many like to use 32s for small game hunting, they universally say SWC and other better bullet types dramatically improve the effects on animals, which also reflects my results from larger rounds. If you cant load or find decent loads and had to rely on RN bullets Id be very hesitant. YMMV. After seeing rabbits get up and run off after body hits with 44 spl, 45 Colt and 45 auto RN loads, it sort of changes your outlook.