I have an old Lyman Orange Crusher single stage press and a nearly new Lee turret press with auto indexing and quick change 4 hole interchangeable turrets. I use the Lyman single stage for rifle and the Lee for handgun. Once the turret is set up you can switch between calibers by swapping out the turret. If you change bullets you'll likely have to adjust the bullet seating die but everything else is ready. You can use the press similar to a single stage and perform only resizing on all cases by not fully raising the press handle. If you run each case through the turret cycle you need to add powder when the case is belled, either through a funnel or an installed auto index powder measure. The Lee press is a very well made press for the money.