Regardless of caliber, I think it's hard to go wrong with either HST or Gold Dots. They would be my first choice if I were to get a new gun and wanted to test self-defense ammo for carry use.
Generally, I prefer medium-to-heavy weight HP bullets for self defense. They seem to offer the best balance between expansion and penetration.
I carry a 642 and my first choice load is the Speer 135gr SB-GDHP +P. My second choice would be some version of the FBI load, with my preferred version being the Buffalo Bore 158gr LSWCHP standard pressure.
I would feel comfortable carrying anything from Doc Robert's list, again with a preference toward's medium-to-heavy weight bullets.
With the exception of Buffalo Bore (and possibly CorBon), I'm more comfortable sticking with one of the major manufacturerers: Speer, Federal, Winchester, Remington. Just my preference.
Most importantly, though, is the reliability of the ammo in my gun and how well I can shoot it.
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