Comfortable ? Yes.
I carry a 3" model 64 every day. It happens to be what I shoot best...and like the best. I practice drawing from concealment, snap shooting at various distances, fast reloads, as well as normal shooting....all the time. My shooting practice consists of single action, double action, "double tap" shooting and rapid fire, all at varying distances and target sizes.
I make no extravagant claims. But, given my age, etc....I am about as prepared as I can be. That, in my opinion, is more important than what actual hardware one carries.
So yes, I am comfortable with only a lowly 6-shot, 38 spl. revolver.