The range of weapons that will swallow and fire 38 LC is pretty broad, as is their pressure capacity. As most have said above, if you load a fast burning, non-pressure sensitive powder like Bullseye, Unique or W-231/HP-38 in a mid-range load you should be fine, but consider carefully what you shoot those 25 rounds in. This is not a time to fool around with your classic collectible Colt or S&W. Shoot them in something cheap, new, and strong.