Most all standard .22 LR ammo is optimized for use in handguns and rifles. It is a **** shoot, however, which ammo will function best in which particular gun.

There are higher grades of speciality .22 match ammo who's powder formulation and bullet shape is geared specifically to rifles or handguns. This ammo should not be needed, however, for any regular production firearm to run properly, and is not always the most accurate in a particular gun. Enough experimentation with decent bulk ammo will find one that is accurate and reliable in your .22

Larry