That's a huge gun to carry in a horizontal shoulder holster so you're probably going to gravitate to a vertical one, maybe even with a belt loop on the gun side. My "backup" gun for the winter used to be a Model 25-5 with a 4" barrel and a Jackass (Galco) worked well for that but it was under a fairly tight uniform Ike jacket so concealing it wasn't an issue.

Is it for a work situation or everyday non-work carry or hunting?

"Comfort" is going to be very relative with a gun that big in a shoulder holster.