I have a 22C in the house for my wife since she doesn't like shooting larger calibers. But as someone said you have to find a round that runs well in the gun you have. My wife's gun is loaded with CCI 40 Grain Mini Mags. A 22 is not the best SD round but I've watched my wife punch the center of a target out up to 7 yards. So with 10 rounds I feel confident she will at least have something to defend herself if I'm not home.