I wouldn't volunteer to take two .22Shorts either, but doesn't make them a good choice for SD either.
9Mm subcompacts are available the sme size as most .380, and are far better choice. If I just had to have a semi of less than 9mm, I'd rather have a .32acp instead. Nearly same power, better penetration-expansion tradeoffs, much o ss recoil, leading to better practical shot placement.
And Skeeter carried a Walther PP in his boot top, not a PPK.