The caliber wars go on and on. I have 2 .380s, a Walther PPK/S and a Beretta model 84. The main reason I own these pistols is that they score high on 'cool factor'. I do keep the Beretta in my night stand (accompanied b a CA Bulldog) and I feel OK with it. My away from home carry piece is usually a Glock 23 or a Smith Model 36.

You can inflict a lethal wound on someone with a .22. Who wants that? If I have to use a firearm for defense, it's first purpose will be to intimidate. This is after I have exhausted all opportunities to avoid the situation to begin with. If I can stop the threat by retreating I will do so.

I'm sure that there's somebody out there with a loaded .500 S&W Magnum in their car. They'll need to hit with the first shot, hope there's no bystanders within 1/2 a mile, and know a good audiologist. Carry what you shoot well.