I've seen homicides with 22's, 380's, 40's, 45's, and lowly FMJ 38 spl from a snub nose. One thing in common was hitting vital organs or brain/spinal shots.
I shoot a full size Glock 45 really well, but carry a J frame daily cause it's easy to have with me and I can shoot it accurately enough.
Situational awareness has saved me more times that the gun I choose to carry, on duty or off.
Stay safe my friends.