In over 40 years carrying my BHP with a Model 36 backup I have heard of more killed with a 22lr than any of the calibres mentioned. Having been shot myself, the first critical seconds referenced are used by the one shot to figure out just what happened. The stopping of the person is mainly his inertia since when he finds he was hit, the fight spirit rapidly goes out of him. So I would say that the 380 can be very effective if it penetrates well and is accurately shot in a reliable pistol.