As we downsize our carry gun for ease of carry, we get less rounds and the caliber naturally gets smaller, and thus, weaker. I've seen people shot with a lot of different calibers and bullet placement is king.
Since I retired I carry a LCP in 380 except if I am going near Detroit or some other danger zone.
The advancements in bullet design have certainly helped with all calibers and I prefer the 380 Gold Dots.
Not to worry about accuracy at 7 yards / 21 feet, most shootings rarely are at that long of a distance and will simply be point and shoot while you have an adrenaline dump.
Bottom line. Carry the biggest caliber with the most round capacity that you have confidence in, can carry comfortably and get to quickly.