WoW!Tall order you got there!But I think there's an answer to every problem.Here is what I think.First,like FredJ338 said(and I too had lots of crushed primers in auto index press),a primer might/will detonate only if it gets an impact.Don't go slamming the ram up and it shouldn't happen.
As for your output target vs tool to use within the parameters you have,I wouldn't go with an auto-indexing press but rather with a manual indexing one,like the 550.
I've got both of them and my goals being similar to yours,if I'd have known,I'd have gone manual indexing with both.I know,the output is a little less with manual but I load for fun and I don't have as much fun when I keep wondering if everything is under control.
Qc