Good and interesting question! 3 identical bullets in different weights, at their corresponding velocities. The truth about the best of these three is whichever shoots best and to the sights in your gun. I at one time had 17 handguns in 45 ACP, all but 2 liked 230 grain (of any quality brand!) but the 2 liked 185 grain and then only one brand (Winchester STHP). All this proves is you have to do some field testing, and when you find what works, stock up on it.

Ivan