I'm of fairly small stature (5' 8" - 160 lbs.) and I shoot everything from .22s up to .44 mag. in both revolvers and semis. It may just be me, but even heavy magnum loads are quite enjoyable to shoot. The only problems I've ever had with the big boys are the plow-handled single action revolvers. They tend to twist in my hand...

The two in the lineup that get the most EDC duty are a S&W M438 and an XDs 9. Both are a treat with defensive loads. Others that get a workout are: S&W M19-3 4", S&W M581 4", Star Firestars in 9mm, .40 S&W and .45 ACP, and a pair of FEG HP clones. All are just plain fun to shoot. But I have to be frugal burning rounds... this retired old geezer has to eat occasionally, too.