As already mentioned, use whatever ammunition is most reliable and hopefully most accurate in your handgun. If you insist on using a .22 for self defense, the eye socket will have to be your target just in case the predator turns out to be some muscled up crank addict that just graduated from your state's school for boys.

Since dirty .22 semiautos jam more often than clean ones, you will need to surgically clean and lube your 22c after every use.