I LOVE 41 Magnum
Out in the wild, where I know trouble exists and I figure it has a good chance to find me, the Winchester Platinum Tip would be my choice. Preferably in a longer barrel than 4.2".
In town, where I am not expecting to find trouble, I am also a big fan of the Barnes 180s. I used to love the Remington Factory 170 SJHPs, but those are long gone from the market place.
The 180 Barnes even perform well from little personal defense revolvers like the 5 shot, 2 1/2" Taurus 415T and 6 shot, 2 1/2" Smith and Wesson Night Guard revolvers.