Wow, there are sure a lot of good pistol powders out there! I like American Select for my 12 ga. target loads. I'm also using it for 9mm, .357 Mag. and .45 ACP loads. I have seen where others are using it for .44 Mag and .38 SPL. It burns cleanly. It won't get you your best velocities, but it will get you in the ballpark, somewhat like Unique. I'm an Alliant kind of guy (formerly Hercules). That being said there are other great brands of powders.