Well, there are really many, many ways to approach it!
I love S&W revolvers and I know I just cannot have them all, they're simply too many.
Me personally, I'm fond of K frames, blued finish preferred.
My
shortest list of "must haves" would include:
J Frame: Model 36
K Frame: Model 10, Model 13, Model 19, Model 14, Model 17
L Frame: Model 586
N Frame: Model 27, Model 29
In there you have a nice selection of .22LR, .38 Special, .357 Magnum and .44 Magnum.
And that's only counting Numbered Hand Ejector Models (post 1957). If you include the tip-ups, top-breaks and pre-numbered hand ejectors, it only gets worse.
Have fun and good luck!