Assuming the brass was all from the same lot it is possible to determine with a reasonable amount of certainty that the charges in the case are all close. Using mixed headstmap brass or even brass all from the same manufacturer but from different periods will make the weight variations be to large to be of any use.
As long as you take precautions on any rounds that has light recoil and avoid shooting a live round into a stuck bullet it should be fine.
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