My EDC is a 642 and I enjoy shooting it...up to a point.

I do most of my shooting with PMC 132gr FMJ which isn't bad to shoot. I also usually put a few cylinder-fulls of +P during each range session, either some older Speer 135gr SB-GDHP +P that I've been carrying and cycling out or Speer Lawman 158gr TMJ +P. My range sessions are usually short, typically 50-60 rounds. I've found my limit is around 75 rounds if I'm including +P, or 100 rounds if I'm only shooting standard pressure ammo. Beyond that, I'm icing my hand afterwards.

A couple of things help. One, I have Spegel's Centennial boot grips, which do a good job of filling my hands but they also have the extended ears that go up the full height of the frame/recoil shoulder, thus helping with felt recoil and controllability. Two, I practice two-handed, right-hand only, and left-hand only shooting, which gives one hand a break while the other hand shoots.