Take ten 22lr bullets set together and you will see that makes for a really big hole. Besides that the 22lr can enter say the shin and still find its way to the heart. The 22lr can be an amazing cartridge.

As far as a 380 IMO it isn't much less felt recoil than many 9mm. In some really small 380 guns the recoil is worse than many 9mm guns.

A 22lr handgun can be very lethal and even a one shot dropper. Added benefit is a 22lr is so much easier on the ears as well as the wallet. Can cost wise sling a lot more shots with 22lr than any other ammo which makes for a whole lot more affordable practice.

All this 22lr talk has got me thinking to get out today and shoot a brick just to see how well or poorly I can shoot with it.