I have seen plenty of folks who met their end thanks to a .22 (or ballistically similar .25). If I were carrying a .22lr in a shorter barrel firearm I would try some 60 grain Aguila SSS. My logic being that nothing is going to have a chance to get fast enough to reliably expand out of a short barrel. The heavier bullet should shed its momentum slower and penetrate better. The SSS has a reputation for tumbling (good AFTER striking the target) so I would make sure your barrel stabilizes it at the distances you are likley to shoot.
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Certified Curmudgeon
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