Comments have been saying to shoot a certain place either center mass or else where .. some very good comments but none may be that useful in the real world !!

Remember its very likely in a self defense situation you will be within 3-10 feet or even closer and you very likely wont have time to bring your weapon up to aim .. extending a weapon at close range is also asking for the perp to take the weapon !!

You may need to be firing from a close to body orientation.. as quickly as you are able to draw and point your pistol at the threat and fire .. you will likely be unable to have both hands on the weapon !! and this should also be practiced .. anywhere in the torso including the pelvic area would be then be a good shot in that situation !!

Practicing drawing and making a head strike on the target with your off hand at the same time as you back away firing is a must practice drill to learn !! Its a scenario that could well play out in real life .. if a perp were to approach you trying to rob you at close quarters !!