Recently I transitioned from 9mm to 22LR for EDC. Arthritis in the hands were the motivation. I thought about 380, but after much research I decided on the 22. It is quite adequate for SD if you are able to be accurate with a succession of shots and use high quality ammo.

I started with CCI Mini Mag in RN and HP. But I am changing to CCI velocitor based upon my continuing research. My Compact 22 has never been fed bulk ammo. I believe in practice with your carry round, and bulk ammo is asking for failures in 22.

I am considering a 22 pocket pistol for those rare times when I just cannot carry my M&P 22 Compact.

The thread I started got pretty long, but it was encouraging because people with experience in SD with a 22 offered a lot of reassurance.

The thread which you should at least browse carefully can be found here.