Cylinder gap is the first thing I check on a wheel gun, followed by lock-up then endshake. If we are good to on all three (kinda hard these days with both Smith and Ruger), then more detailed inspection occurs.

It's a sad state of affairs when a brand new 2017 production magnum wheelgun from S&W, Ruger, Charter or Taurus has a much larger cylinder gap than a wartime emergency 1916 production Webley Mk VI chambered in low pressure .455.