Closest I've gotten to drawing in self defense (thank goodness!!) was to move my 442 from my ankle to my pocket when I was going to a jobsite that had known "threat"....a huge dog that didn't like humans near his territory...

Figured it may be difficult to draw from my ankle with my foot in a dogs mouth.

Thankfully all worked out and me and the dog came to an understanding...I give him lots of room and he doesn't chew my face off!