The concensus has been to put a #61 O-ring (any hardware or plumbing supply should stock them) and a drop of Vibra-Tite VC-3 (available on eBay for $6 for a 5ml tube, which will last you a lifetime!) OR pure silicone on the threads of the take-down screw. I wouldn't recommend using Lock-Tite, unless you use the 'light-strength purple color ONLY' to avoid the risk of permanently locking the take-down screw in place.
Also, don't forget to include an extended length QUALITY hex key (not a ball head, as they break off too easily) or T-handle hex wrench in your range bag with you and check the screw tightness after every 50-100 rounds fired.
There also are improved quality hex head screws offered on eBay for either $7@ or two for $10 (keep the extra in your shooting box) which have a 7/64 opening in the head for greater access and grip.
I've gone the route with the improved screw, #62 O-ring, and a little dab of VC-3, and have not had any problems to date.
It's really not a MAJOR issue, and if you're prepared, you shouldn't have a problem.
"Keep yer powder dry!"
Echo 47