As noted above, frequent use will result in wear to the hand. The hand is a standard maintenance item and should be checked periodically and replaced if necessary.

Would it keep me from using a Python? Absolutley not.

Should the time come that you need to replace the hand, I can highly recommend Frank Glenn. He did a great job on a pair of Colt "357"s for me.

See post #2 from this thread for how to check out a Colt DA: Educate Me On Colt DAs | The High Road