As an exercise, I used the Quickload interior ballistics program to assess a .44 Russian load using a 180 grain bullet and 4.0 grains of Bullseye. With a 6" barrel, the calculated peak pressure was 6593 psi with a MV of 707 ft/sec. That's very mild. My experience with Quickload is that it provides optimistic MVs, so I would expect (especially in a revolver) a chronographed MV closer to 650 ft/sec. Increasing the bullet weight to 240 grains raises the calculated peak pressure to 7800 psi and drops the MV to 666 ft/sec. Thus my preference for using lighter bullets to keep the peak pressure down.

Substituting Clays for Bullseye and with the same 180 grain bullet, approximately the same MV is achieved with 2.9 grains, but the calculated peak pressure is increased to about 7300 psi.