I never went that heavy in my K frame .357 revolvers, since I did not kill Bowling pins.

I did go with the old Speer 160gr lead tip Jacketed bullet as a
deer killing machine, here in Nevada, though.

I got Unique up to1230fps as my most accuracy load...
I did not have any 2400 powder at the time.
Blue Dot did 1270fps but was not as accurate.

As a note, a 158 with 2400 in a 6" does 1340fps with a XTP .

Enjoy those heavy bullets.